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REVIEW ARTICLE
Year : 2014  |  Volume : 17  |  Issue : 2  |  Page : 69-75

Cathelicidin expression and role in oral health and diseases: A short review


1 Department of Oral and Maxillofacial Pathology, Vipula Care Hospital, Vijayawada, Andhra Pradesh, India
2 Department of Oral and Maxillofacial Pathology, Amrita School of Dentistry, Kerala, India
3 Department of Oral and Maxillofacial Pathology, Azeezia Dental College and Research, Kollam, Kerala, India
4 Department of Oral Medicine and Radiology, Azeezia Dental College and Research, Kollam, Kerala, India

Correspondence Address:
Prem Anand Prabhakaran
Department of Oral and Maxillofacial Pathology, Amrita School of Dentistry, Kerala
India
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DOI: 10.4103/1119-0388.140414

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The oral cavity is a unique environment in which antimicrobial peptides play a key role in maintaining health. Cathelicidins are small cationic antimicrobial host defense peptides that possess broad-spectrum antimicrobial activity. Humans possess a single cathelicidin, which was first cloned from human bone marrow cDNA. Its mature form is known as LL-37. Various immune and epithelial cells secrete LL-37, and its level varies in response to caries, periodontal, congenital, inflammatory, and malignant diseases in the oral region. Human cathelicidin peptide LL-37 exhibits antimicrobial activity against bacteria that cause oral pathological conditions, including cariogenic disease and periodontitis. Further research on LL-37 is needed as its usefulness as a new class of antimicrobial drugs still remains to be proven and may have future therapeutic applications.


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