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Year : 2015  |  Volume : 18  |  Issue : 1  |  Page : 5-9

Diagnostic utility of anti-CCP antibodies and rheumatoid factor as inflammatory biomarkers in comparison with C-reactive protein and TNF-α in rheumatoid arthritis

1 Department of Microbiology, Maulana Azad Medical College, New Delhi, India
2 Department of Microbiology, University College of Medical Sciences, Guru Tegh Bahadur Hospital, New Delhi, India
3 Department of Medicine, University College of Medical Sciences, Guru Tegh Bahadur Hospital, New Delhi, India

Correspondence Address:
Dr. Bineeta Kashyap
Flat No. C-402, Vimal CGHS Ltd, Plot-3, Sector-12, Dwarka, New Delhi - 100 078
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DOI: 10.4103/1119-0388.152534

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Aims and Objectives: Rheumatoid arthritis is a systemic inflammatory disease whose diagnosis is primarily based on clinical manifestations because of lack of suitable diagnostic tests. As substantial joint damage already occurs by the time patient presents clinically, a validated biomarker for the diagnosis is urgently required. Materials and Methods: Sera from a total of 68 clinically suspected rheumatoid arthritis patients and 68 age-and sex-matched controls were tested for rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) antibodies, C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-α). Results: Anti-CCP and CRP were found to be positive in all patients with positive RF; however, TNF-α was present in only two of them. As regards anti-CCP antibodies, out of the 10 samples that showed positive results, RF, CRP, and TNF-α were also present in 4, 5, and 4 cases, respectively. Conclusion: The recognition of utility of such markers is essential to gain insight into the activity of this disease, which is important for early treatment that may limit functional disability consequent to the disease.

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