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Year : 2016  |  Volume : 19  |  Issue : 1  |  Page : 68-70

Squamous cell carcinoma in a patient with epidermodysplasia verruciformis

1 Department of Medicine, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria
2 Department of Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria

Correspondence Address:
Ogochukwu Ifeanyi Ezejiofor
Department of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State
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DOI: 10.4103/1119-0388.172072

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Epidermodysplasia verruciformis (EV) is a rare autosomal recessive disease, characterized by early onset and lifelong occurrence of multiple flat warts. Infections with various serotypes of human papillomavirus (HPV) have been implicated. Defects in cell-mediated immunity have also been implicated in causing persistent viral infections and with continual exposure of such lesions to ultraviolet light transforms them to squamous cell carcinoma. This case report exemplifies such an association and advocates the need for early sun protective measures in individuals who suffer this disorder to prevent malignant transformation.

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