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REVIEW ARTICLE
Year : 2017  |  Volume : 20  |  Issue : 2  |  Page : 127-131

Current state of salivaomics and metabolomic profiling as novel diagnostics for biomarker research and applications in oral cancer and personalized medicine


1 Department of Oral Medicine and Radiology, Kothiwal Dental College and Reasearch Centre, Moradabad, Uttar Pradesh, India
2 Department of Oral Pathology and Microbiology, Kothiwal Dental College and Reasearch Centre, Moradabad, Uttar Pradesh, India

Correspondence Address:
Simi Thankappan
Department of Oral Medicine and Radiology, Kothiwal Dental College and Reasearch Centre, Moradabad, Uttar Pradesh
India
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DOI: 10.4103/tjmr.tjmr_28_16

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Biomarkers are the main focus of current researches in biological characteristics that are easily measured in patients, and their discovery has laid the foundation for personalized medicine. Salivaomics and metabolomics are the rapidly emerging diagnostics focused on comprehensive profiling of metabolites in intracellular or biofluid sample. A systematic search of PubMed Central, Ebsco Host, Science Direct, and Scopus was done and the search terms included salivaomics, metabolomics, biomarkers, metabolites, oral cancer, proteomics, personalized medicine, and omics. This review article summarizes on the significance of salivary metabolites as diagnostic and prognostic biomarkers due to different biochemical pathways in oral cancer patients and healthy controls, even early detection of cancer in patients, thus emphasizing on the rigorous need of future research in this field.


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